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Others choose every one to two weeks

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

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And if you want to make a direct connection Puno City Lake Titicaca after the Colca Canyon, you also have this option of 2 days in the Colca with transfer to Puno